I have been taking ConoCB2 now for approximately 2 months and have no pain in my wrists or back that I used to before taking this product. I used to take Ibprofen and other meds for pain but they only worked short term. Colonadine seems to solve all my pain problems and I’m so glad I tried this. I use other GDR products too and have no side effects. Thank you GDR for all your products.