I have had rather severe shoulder issues from years of abuse….heavy lifting as a gym rat. It got so severe I was having trouble sleeping. I tried topicals in the past, not much luck. Then I used out of sheer hope Conolidine Topical. A few applications in and I actually felt some relief. Constant use (3) times per day yielded amazing results. Have purchased 3 times now, and am about to make my 4th. Great product.